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Most patients exhibit a decreased and disorganized background rhythm, along with focal or multifocal sharp waves during the interictal period ( MT-ND1 mutation demonstrated decreased background activity, multifocal epileptic discharges, and significant irregularity ( MRI findings in LS often help elucidate the underlying etiology, with classic abnormalities involving the basal ganglia, particularly the bilateral putamen, periaqueductal gray, and brainstem ( SURF-1 mutations, symmetrical involvement of the bilateral brainstem and subthalamic nuclei is common, and some patients exhibit basal ganglia abnormalities

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doi: 10.1155/2018/6484839

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