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Variants were analyzed according to best practice guidelines for the evaluation of pathogenicity and the reporting of sequence variants in clinical molecular genetics (2020, Association for Clinical Genomic Science, Confirmation of clinically significant sequence variants by Sanger sequencing was performed as necessary

Antiepileptic drugs interact with folate and vitamin B 12 serum levels

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This step is especially important when peptides will be combined or drawn frequently

Liver function tests (LFTs) should be performed to assess disease activity and guide overall management