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These transgenerational effects operate primarily through epigenetic modifications, germline transmission of molecular alterations, and persistent fertility impairments that challenge traditional concepts of toxicological risk assessment (84)
Recent studies have indicated that susceptibility genes for LN (disrupting immune tolerance) can enhance the innate immune signaling pathway, promoting lymphocyte activation and leading to kidney damage [130]
However, intervention studies have shown only marginal effects of vitamin D supplementation on autoantibody levels without further clinical benefit [103, 106, 107]
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