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Advanced molecular studies reveal that FOXO4-DRI promotes p53 nuclear exclusion and subsequent mitochondrial targeting, where p53 interacts with BCL-2 family proteins to promote mitochondrial outer membrane permeabilization and cytochrome c release

Their combined action ensures continuous support against oxidative stress

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Confocal and STED images were acquired using an Abberior microscope setup (Abberior Instruments GmbH) including Olympus IX83 microscope body and Imspector software (version 16.3.15521-w2209)

"A Multicenter Randomized Noninferiority Trial Comparing GreenLight-XPS Laser Vaporization of the Prostate and Transurethral Resection of the Prostate for the Treatment of Benign Prostatic Obstruction: Two-yr Outcomes of the GOLIATH Study"