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The transcriptomic approach was done under these two conditions so that we would obtain an unbiased insight into (a) the possible pathways or proteins that were targets of 5-OP leading to their inactivation and consequently the effect on growth and (b) the cellular response to 5-OP toxicity enabling the cells to tackle the 5-OP treatment and accumulation

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The Broad Institute CMap provides powerful data but uses specific cell lines and conditions that may not perfectly represent all tissue types

PubMed Central , Frontiers in Immunology , vol

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