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PRISMA flow diagrams describing the selection process of the studies identified in the literature searches are provided in Additional file 1: Appendix 5b,c

Where did the remaining two trials go

Lady Gaga reveals weed addiction, admits smoking a whopping "15 joints every day" In a shock confession, the Applause singer admits to smoking 15 joints a day to help numb the pain of her agonising hip injury Superstar songstress Lady Gaga has revealed she became hooked on weed and was smoking up to "15 joints a day" in a shock new interview

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In addition, tobacco use has been indicated to have several effects on the hypothalamus-pituitary-thyroid axis and the function of the thyroid gland